LifeStory is a flexible interactive learning game framework that incorporates mobile technology, game technology, learning, ecology, North American Indigenous epistemologies, and science education. Users of LifeStory are encouraged to take on the perspectives of non-human actors in ecosystems as they play through pre-packaged life stories of non-human characters or build their own playable stories. It can be used in concert with outdoor education, Indigenous science, Indigenous knowledge systems, digital storytelling, and mainstream science education initiatives. LifeStory enacts STEAM (STEM plus Art) learning in an interactive user-directed game building environment. It also encourages perspectives of the natural world that are empathetic, engage systems thinking and enact North American Indigenous epistemologies.